USE OF A METALLATION REACTION TO OBTAIN SUBSTITUTED 2-(5-METHYL-2-THIAZOLYL)ETHANOLS

Authors

  • А. Ю. Лякина M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997
  • А. А. Формановский M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997
  • И. С. Попова M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997
  • И. В. Михура M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997

DOI:

https://doi.org/10.1007/8251

Keywords:

butyllithium, 2, 5-dimethyl-4-phenylthiazolide anion, 2-thiazolylethanols, metallation

Abstract

The interaction of anions, obtained by treating 2,4,5-trimethylthiazole and 2,5-dimethyl-
4-phenylthiazole with butyllithium, with aliphatic and aromatic aldehydes leads to substituted 2-thiazolyl-1-ethanols. It was established that the metallation reaction occurs at the 2-methyl group of the thiazoles.

How to Cite
Liakina, A. Yu.; Formanovsky, A. A.; Popova, I. S.; Mikhura, I. V.  Chem. Heterocycl. Compd. 2005, 41, 877. [Khim. Geterotsikl. Soedin. 2005, 1038.]

For this article in the English edition, see DOI 10.1007/s10593-005-0242-0


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Published

2023-11-01

Issue

No. 7 (2005)

Section

Original Papers