SYNTHESIS OF 5-(ARYLAMINO)-1-BENZYLURACILS

Authors

  • М. С. Новиков Research Institute of Pharmacology, Volgograd State Medicinal University, Volgograd 400131
  • А. А. Озеров Research Institute of Pharmacology, Volgograd State Medicinal University, Volgograd 400131

DOI:

https://doi.org/10.1007/8277

Keywords:

5-(arylamino)-1-benzyluracil, 2, 4-bis(trimethylsilyloxy)pyrimidine, 5-bromouracil, N(1)-alkylation, C(5)-amination

Abstract

The synthesis of novel 5-(phenylamino)-, 5-(benzylamino)-, and 5-(phenethylamino) derivatives of 1-benzyluracil-containing different substituents in the aromatic nucleus has been carried out. Using the Hilbert–Johnson reaction it was found that N(1)-monosubstitution can be achieved via alkylation of trimethylsilyl derivatives of 5-(arylamino)uracils using benzyl bromide.

How to Cite
Novikov, M. S.; Ozerov, A. A.  Chem. Heterocycl. Compd. 2005, 41, 766. [Khim. Geterotsikl. Soedin. 2005, 887.]

For this article in the English edition, see DOI 10.1007/s10593-005-0218-0


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Published

2023-11-08

Issue

No. 6 (2005)

Section

Original Papers