NEW PROCEDURE FOR OBTAINING INDOMETHACIN

Authors

  • И. В. Магедов Moscow K. A. Timiryazev Agricultural Academy, Moscow 127550
  • С. А. Маклаков Novomoscovsk Institute of the Russian D. I. Mendeleev University of Chemical Technology, Novomoscovsk 301670
  • Ю. И. Смушкевич Russian D. I. Mendeleev University of Chemical Technology, Moscow 125047

DOI:

https://doi.org/10.1007/8320

Keywords:

indomethacin, catalysis with sodium hydrogen sulfate, Fischer reaction

Abstract

A new procedure has been developed for the synthesis of indomethacin by the Fischer reaction, based on the acylation of sodium 2-(4-methoxyphenyl)-1-hydrazosulfonate with 4-chlorobenzoyl chloride and subsequent interaction with levulinic acid in the presence of formic acid.

How to Cite

Magedov, I. V.; Maklakov, S. A.; Smushkevich, Yu. I.  Chem. Heterocycl. Compd. 2005, 41, 449. [Khim. Geterotsikl. Soedin. 2005, 530.]

For this article in the English edition, see DOI 10.1007/s10593-005-0169-5


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Published

2023-11-16

Issue

No. 4 (2005)

Section

Original Papers