STUDY OF NITROGEN- AND SULFUR-CONTAINING HETEROCYCLES. 57. SYNTHESIS AND CONVERSION OF 4'-SUBSTITUTED 5-(5-AMINO-6-PYRIMIDYLTHIO)-2,2-DIMETHYL-4,6-DIOXO-1,3-DIOXANES

Abstract

By reaction of 4-substituted 5-amino-6-mercaptopyrimidines with 5-bromo-2,2-dimethyl-4,6-dioxo-1,3-dioxane, we have obtained 4'-substituted 5-(5-amino-6-pyrimidylthio)-2,2-dimethyl-4,6-dioxo-1,3-dioxanes. We have studied diazotization of these compounds by isoamyl nitrite. In the case of 4'-methoxy- and 4'-dimethylamino-substituted derivatives, we have obtained derivatives of novel heterocyclic systems: pyrimido[5,4-e][1,3,4]thiadiazine and pyrimido[5,4-e][1,3,4]thiadiazine-7-spiro-5'-1,3-dioxane, and in the case of the 4'-isopropylamino-substituted derivative we obtained 4-isopropyl-7-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-1,2,3-triazolo[5,4-d]pyrimidin-7-ylidene.

How to Cite
Safonova, T. S.; Nemeryuk, M. P.; Likhovidova, M. M.; Sedov, A. L.; Keremov, A. F.; Solov'eva, N. P.; Anisimova, O. S.  Chem. Heterocycl. Compd. 2005, 41, 526. [Khim. Geterotsikl. Soedin. 2005, 613.]

For this article in the English edition, see DOI 10.1007/s10593-005-0182-8