2-METHYLTHIO-4,5,6,7-TETRAHYDRO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PYRIMIDIN-5- AND -7-ONES

Authors

  • В. В. Липсон V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Ukraine Academy of Medical Sciences, Kharkov 61002
  • С. М. Десенко STC Institute for Single Crystals, Kharkov 61001
  • В. В. Бородина V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Ukraine Academy of Medical Sciences, Kharkov 61002
  • М. Г. Широбокова V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Ukraine Academy of Medical Sciences, Kharkov 61002
  • Т. М. Карножицкая V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Ukraine Academy of Medical Sciences, Kharkov 61002
  • В. И. Мусатов STC Institute for Single Crystals, Kharkov 61001
  • С. В. Кравченко V. Ya. Danilevsky Institute of Endocrine Pathology Problems, Ukraine Academy of Medical Sciences, Kharkov 61002

DOI:

https://doi.org/10.1007/8377

Keywords:

3-amino-5-methylthio-1, 2, 4-triazole, arylidene derivatives of Meldrum's acid, methylcinnamates, partially hydrogenated 1, 4-triazolo[1, 5-a]pyrimidinones, cyclocondensation

Abstract

The cyclocondensation of methylcinnamates and arylidene derivatives of Meldrum's acid with 3-amino-5-methylthio-1,2,4-triazole in DMF gives 2-methylthio-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]-pyrimidin-5-ones. The reaction involving arylidene derivatives of Meldrum's acid or its synthetic equivalents in ethyl acetate with a catalytic amount of pyridine gives a mixture of 2-methylthio-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidin-5- and -7-ones.

How to Cite
Lipson, V. V.; Desenko, S. M.; Borodina, V. V.; Shirobokova, M. G.; Karnozhitskaya, T. M.; Musatov, V. I.; Kravchenko, S. V. Chem. Heterocycl. Compd. 2005, 41, 216. [Khim. Geterotsikl. Soedin. 2005, 246.]

For this article in the English edition, see DOI 10.1007/s10593-005-0130-7


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Published

2023-12-01

Issue

No. 2 (2005)

Section

Original Papers