SYNTHESIS OF 5-AMINO-4-HETARYL-2,3-DIHYDRO-1H-3-PYRROLONES

Authors

  • А. В. Твердохлебов Taras Shevchenko Kiev University, Kiev
  • А. Б. Ляшенко Taras Shevchenko Kiev University, Kiev
  • Ю. М. Воловенко Taras Shevchenko Kiev University, Kiev
  • А. А. Толмачев Taras Shevchenko Kiev University, Kiev

DOI:

https://doi.org/10.1007/8419

Keywords:

5-amino-4-hetaryl-2, 3-dihydro-1H-3-pyrrolones, hetarylacetonitriles, γ-phthalimidonitriles, N-phthaloylamino acids

Abstract

2-Hetaryl-3-oxo-4-phthalimidobutyronitriles (and pentanonitriles) were obtained with high yields by C-acylation of hetarylacetonitriles with N-phthaloylglycine and α-alanine chlorides respectively under the conditions of base catalysis. Hydrazinolysis of the phthaloyl protection in these compounds leads to the formation of 5-amino-4-hetaryl-2,3-dihydro-1H-3-pyrrolones.

How to Cite
Tverdokhlebov, A. V.; Lyashenko, A. B.; Volovenko,Yu. M.; Tolmachev, A. A.  Chem. Heterocycl. Compd. 2004, 40, 1536. [Khim. Geterotsikl. Soedin. 2004, 1783.]

For this article in the English edition, see DOI 10.1007/s10593-005-0095-6


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Published

2023-12-08

Issue

No. 12 (2004)

Section

Original Papers