<i>N</i>-ARYL-<i>C</i>-NITROAZOLES. 1. <i>C</i>-NITRO-<i>N</i>-PHENYLAZOLES

Abstract

Several synthetic approaches to differently substituted nitroazoles and their applications have been described in literature. Recently, some N-aryl-C-nitroazoles proved to be promising antibacterial, antiprotozoal agents, as well as explosives. However, their synthesis and applications are not well developed. Syntheses of N-aryl-C-nitroazoles are reviewed here for the first time. Part 1 is devoted to synthesis of C-nitro-N-phenylazoles treated in this review as parent compounds. Procedures of selected compounds have been given and their properties verified. Part 2 will contain related information on the derivatives containing additional substituents in one or both aromatic rings. In Part 3, N-aryl group in C-nitroazoles will be replaced by N-heteroaryl substituent. Non-aromatic compounds and nitroazoles containing ring heteroatom other than nitrogen will not be included in the review.

Also published in Chemistry of Heterocyclic Compounds, 2013, 48 (12), pp 1737-1750

http://link.springer.com/article/10.1007/s10593-013-1205-5