RING EXPANSION STRATEGY TO ACCESS FUNCTIONALIZED 2-OXAZOLINES

Authors

  • Leyan Liu College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620
  • Wentong Liu College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620
  • Huangdi Feng College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620

Keywords:

Ring expansion, oxazoline, azacycle

Abstract

The development of innovative methods for the construction of heterocycles is an important topic in synthetic and medicinal chemistry. Ring expansion strategies, involving the cyclization of strained aza rings, have been well developed in the synthesis of diverse heterocyclic compounds. This microreview summarizes recent advances in the ring expansion reactions of aziridines, oxetanes, and azetidines to access a series of functionalized 2-oxazolines, which are versatile structural motifs in drugs and bioactive molecules.

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Published

2024-08-01

Issue

Vol. 60 No. 5/6 (2024)

Section

Heterocycles in Focus