SYNTHESIS OF 7-OXOPYRROLO[3,2-<i>d</i>]PYRIMIDINE 5-OXIDES BY THE REARRANGEMENT OF 6-ALKYNYL-5-NITROPYRIMIDINES

Authors

  • S. Tumkevicius Organic Chemistry Department, Vilnius University, Vilnius LT-03225
  • I. Susvilo Organic Chemistry Department, Vilnius University, Vilnius LT-03225
  • A. Brukstus Organic Chemistry Department, Vilnius University, Vilnius LT-03225

DOI:

https://doi.org/10.1007/s10593-005-0074-y

Keywords:

alkynes, nitropyrimidines, palladium, pyrrolo[3,2-d]pyrimidines, catalysis, rearrangement

Abstract

A method is proposed for the synthesis of 6-substituted 4-amino-7-oxopyrrolo[2,3-d]pyrimidine 5-oxides which includes a Sonogashira reaction of 4-amino-6-chloro-5-nitropyrimidine with terminal alkynes and subsequent rearrangement of the 6-alkynyl-5-nitropyrimidines obtained.

How to Cite
Tumkevicius, S.; Susvilo, I.; Brukstus, A. Chem. Heterocycl. Compd. 2004, 40, 1335. [Khim. Geterotsikl. Soedin. 2004, 1546.]

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Published

2004-10-25

Issue

No. 10 (2004)

Section

Original Papers