CYCLOCONDENSATION OF 2-FLUORO-5-NITROBENZALDEHYDE WITH AMIDINES. NEW SYNTHESIS OF ISOQUINOLINES

Authors

  • D. V. Dar'in St. Petersburg State University, Saint Petersburg 198504
  • S. I. Selivanov St. Petersburg State University, Saint Petersburg 198504
  • P. S. Lobanov St. Petersburg State University, Saint Petersburg 198504
  • A. A. Potekhin St. Petersburg State University, Saint Petersburg 198504

Keywords:

amidines as N,N- and C,N-dinucleophiles, isoquinolines, 2-fluoro-5-nitrobenzaldehyde, cyclocondensation

Abstract

The direction of the cyclocondensation of 2-fluoro-5-nitrobenzaldehyde with five amidines having α-hydrogen atoms has been studied. It was established that depending on the structure of the amidine the main products of the reaction may be not only quinazolines but also 3-aminoisoquinolines. A new convenient route has been found for the synthesis of 3-aminoisoquinolines consisting of the cyclocondensation of α-acylacetamidines with 2-fluoro-5-nitrobenzaldehyde.

How to Cite
Dar'in, D. V.; Selivanov, S. I.; Lobanov, P. S.; Potekhin, A. A. Chem. Heterocycl. Compd. 2004, 40, 888. [Khim. Geterotsikl. Soedin. 2004, 1036.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000044571.89322.4e

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Published

2004-07-25

Issue

No. 7 (2004)

Section

Original Papers