SYNTHESIS AND CYTOTOXICITY OF DERIVATIVES OF DI(3-INDOLYL) SELENIDE

Authors

  • E. Abele Latvian Institute of Organic Synthesis, Riga LV 1006
  • J. Popelis Latvian Institute of Organic Synthesis, Riga LV 1006
  • I. Shestakova Latvian Institute of Organic Synthesis, Riga LV 1006
  • I. Domracheva Latvian Institute of Organic Synthesis, Riga LV 1006
  • P. Arsenyan Latvian Institute of Organic Synthesis, Riga LV 1006
  • E. Lukevics Latvian Institute of Organic Synthesis, Riga LV 1006

Keywords:

indole, selenides, phase-transfer catalysis, cytotoxicity

Abstract

A method has been developed for the synthesis of di(3-indolyl) selenides. From indole and SeO2. N-Alkyl derivatives of di(3-indolyl) selenide have been obtained in the two-phase system alkyl halide–solid K2CO3 (or KOH)–18-crown-6–toluene. It was discovered that N-unsubstituted di(3-indolyl) selenides possess high cytotoxicity on HT-1080 and MG-22A tumor cell lines.

How to Cite
Abele, E.; Popelis, J.; Shestakova, I.; Domracheva, I.; Arsenyan, P.; Lukevics, E. Chem. Heterocycl. Compd. 2004, 40, 742. [Khim. Geterotsikl. Soedin. 2004, 868.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000040769.55088.e3

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Published

2004-06-25

Issue

No. 6 (2004)

Section

Original Papers