SYNTHESIS OF QUINOLINE-8-SELENOL, ITS COMPLEX COMPOUNDS WITH METALS AND THEIR CYTOTOXIC ACTIVITY

Authors

  • J. Ashaks Institute of Inorganic Chemistry, Riga Technical University, Salaspils LV-2169
  • Yu. Bankovsky Institute of Inorganic Chemistry, Riga Technical University, Salaspils LV-2169
  • D. Zaruma Institute of Inorganic Chemistry, Riga Technical University, Salaspils LV-2169
  • I. Shestakova Latvian Institute of Organic Synthesis, Riga LV 1006
  • I. Domracheva Latvian Institute of Organic Synthesis, Riga LV 1006
  • A. Nesterova Latvian Institute of Organic Synthesis, Riga LV 1006
  • E. Lukevics Latvian Institute of Organic Synthesis, Riga LV 1006

Keywords:

quinoline-8-selenol, metal quinoline-8-selenolates, cytotoxicity

Abstract

We have developed a novel method for synthesis of quinoline-8-selenol using selenourea instead of the previously used potassium selenocyanate. We have synthesized a series of metal quinoline-8-selenolates. We have studied the cytotoxic activity of the synthesized compounds against HT-1080, MG-22A, B16, Neuro 2A tumor cells. Mercury quinoline-8-selenolate is distinguished by high cytotoxicity for the three cell lines; the cadmium complex is most effective against B16 melanoma cells.

How to Cite
Ashaks, J.; Bankovsky, Yu.; Zaruma, D.; Shestakova, I.; Domracheva, I.; Nesterova, A.; Lukevics, E. Chem. Heterocycl. Compd. 2004, 40, 776. [Khim. Geterotsikl. Soedin. 2004, 905.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000040774.96325.d1

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Published

2004-06-25

Issue

No. 6 (2004)

Section

Original Papers