PSYCHOTROPIC PREPARATIONS SYDNOPHEN AND SYDNOCARB AS DONORS OF NITROGEN MONOXIDE

Authors

  • В. И. Левина "NIOPIK" State Science Center of the Russian Federation, Moscow 10378
  • Н. Б. Григорьев "NIOPIK" State Science Center of the Russian Federation, Moscow 10378
  • В. Г. Граник "NIOPIK" State Science Center of the Russian Federation, Moscow 10378

Keywords:

nitroprusside anion, nitrogen monoxide NO, Sydnocarb, Sydnophen, hydrolysis, polarographic detection, oxidation

Abstract

The metabolic chain of the antihypertensive drug Molsydomin, which belongs to the group of sydnonimine derivatives, was modelled in vitro with the psychotropic drugs Sydnophen and Sydnocarb, which are also derivatives of sydnonimine. Like Molsydomin, Sydnophen and Sydnocarb are hydrolyzed to N-nitroso compounds which liberate nitrogen monoxide, NO, on subsequent oxidation which may be related to the pharmacological effects of these drugs.

How to Cite
Levina, V.; Grigor'ev, N. V.; Granik, V. G. Chem. Heterocycl. Compd. 2004, 40, 507. [Khim. Geterotsikl. Soedin. 2004, 604.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000033547.16697.61

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Published

2004-04-25

Issue

No. 4 (2004)

Section

Original Papers