THE SYNTHESIS OF ETHYL 2-AMINO-1-(ARYL)-5-(ARYLCARBAMOYL)- 6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXYLATES

Authors

  • Anush Khachatryan Senior science employee https://orcid.org/0000-0003-1210-9903
  • Katya Avagyan Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia
  • Anush Sargsyan Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia https://orcid.org/0000-0002-0303-0710
  • Anahit Simonyan Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia https://orcid.org/0009-0003-3868-4022
  • Henrik Panosyan Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia https://orcid.org/0000-0001-8311-6276
  • Armen Ayvazyan Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia https://orcid.org/0000-0002-3224-0549
  • Alik Badasyan Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., Yerevan 0014, Armenia https://orcid.org/0009-0003-6123-9867

Keywords:

N1,N3-diarylmalonamides, ethyl 2-cyano-3-ethoxyacrylates, Michael adducts, Antibacterial Activity, intramolecular heterocyclization, regioselectivity

Abstract

A new method for the synthesis of previously unknown ethyl 2-amino-1-(aryl)-5-(arylcarbamoyl)-6-oxo-1,6-dihydropyridine-3carboxylates by a reaction of ethyl 2-cyano-3-ethoxyacrylate with N1,N3-diarylmalonamides was developed. The antibacterial activity of some of the synthesized compounds was assayed.

 

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Published

2024-05-28

Issue

Vol. 60 No. 3/4 (2024)

Section

Original Papers