9-(2-ARYLOXYETHYL) DERIVATIVES OF ADENINE – A NEW CLASS OF NON-NUCLEOSIDIC ANTIVIRAL AGENTS

Authors

  • В. И. Петров Scientific Research Institute for Pharmacology, Volgograd State Medical University, Volgograd 400131
  • А. А. Озеров Scientific Research Institute for Pharmacology, Volgograd State Medical University, Volgograd 400131
  • М. С. Новиков Scientific Research Institute for Pharmacology, Volgograd State Medical University, Volgograd 400131
  • К. Паннекуик Rega Institute for Medical Research, Catholic University, Leuvain
  • Я. Бальзарини Rega Institute for Medical Research, Catholic University, Leuvain
  • Э. Де Клерк Rega Institute for Medical Research, Catholic University, Leuvain

Keywords:

adenine, N(9)-alkylation, antiviral activity

Abstract

New 9-(aryloxyalkyl) derivatives of adenine have been prepared by alkylation of adenine with tosylates, bromides, and α-chloro ethers containing terminal aromatic fragments in anhydrous DMF in the presence of potassium carbonate. The compounds of the 9-(2-phenoxyethyl)adenine series appear to be highly reactive against cytomegaloviruses of mankind in vitro, while derivatives of 9-(2-benzyloxyethyl)adenine demonstrate anti-HIV-1 activity. Compounds with shorter or longer chains, and also compounds which  do not have aromatic fragments at the ends of the chains, do not possess antiviral activity.

How to Cite
Petrov, V. I.; Ozerov, A. A.; Novikov, M. S.; Pannecouque, C.; Balzarini, J.; De Clercq, E Chem. Heterocycl. Compd. 2003, 39, 1218. [Khim. Geterotsikl. Soedin. 2003, 1389.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000008270.32235.2b

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Published

2003-09-25

Issue

No. 9 (2003)

Section

Original Papers