TRIMETHYLSILYLCYANATION OF HETEROCYCLIC ALDIMINES – DERIVATIVES OF 2-TRIFLUOROMETHYLANILINE

Authors

  • И. Иовель Latvian Institute of Organic Synthesis, Riga LV 1006
  • Л. Голомба Latvian Institute of Organic Synthesis, Riga LV 1006
  • Ю. Попелис Latvian Institute of Organic Synthesis, Riga LV 1006
  • А. Гаухман Latvian Institute of Organic Synthesis, Riga LV 1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV 1006

Keywords:

α-amino nitriles, heterocyclic Schiff bases, Lewis acid, trimethylsilyl cyanide, catalysis

Abstract

he addition of trimethylsilyl cyanide to the CH=N bond of furan, thiophene, and pyridine azomethines in the presence of aluminum bromide as catalyst was studied. The effect of the CF3 group in the aldimines produced by the condensation of O-, S-, and N-heteroaromatic aldehydes with 2-trifluoromethylaniline on the reaction and also other relationships of the investigated processes were studied. The corresponding furan, thiophene, and pyridine α-amino nitriles were synthesized.

How to Cite
Iovel, I.; Golomba, L.; Popelis, J.; Gaukhman, A.; Lukevics, E. Chem. Heterocycl. Compd. 2003, 39, 721. [Khim. Geterotsikl. Soedin. 2003, 847.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1025682726008

Published

2003-06-25

Issue

No. 6 (2003)

Section

Original Papers