SYNTHESIS OF CYTOTOXIC 1,3,4-TRISUBSTITUTED 2-AZETIDINONES

Authors

  • Г. Вейнберг Latvian Institute of Organic Synthesis, Riga LV 1006
  • Р. Бокалдере Latvian Institute of Organic Synthesis, Riga LV 1006
  • К. Диковская Latvian Institute of Organic Synthesis, Riga LV 1006
  • М. Ворона Latvian Institute of Organic Synthesis, Riga LV 1006
  • И. Канепе Latvian Institute of Organic Synthesis, Riga LV 1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV 1006
  • Э. Ященко Latvian Institute of Organic Synthesis, Riga LV 1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV 1006

Keywords:

4-substituted (3S,4S)-1-(4-methoxyphenyl)-3-methyl-2-azetidinones, cytotoxic activity

Abstract

A series of 1,3,4-trisubstituted and 3,4-disubstituted 2-azetidinones were synthesized in order to study the relation between their structure and biological characteristics. Study of the cytotoxic activity of these compounds revealed an anticancer effect in (3S,4S)- 1-(4-methoxyphenyl)-3-methyl-2-azetidinones containing 2-acetoxybenzoyloxymethyl and 2,2-dicyanovinyl substituents at position 4 in vitro with respect to a wide range of monolayer cultures of cancer cells.

How to Cite
Veinberg, G.; Bokaldere, R.; Dikovskaya, K.; Vorona, M.; Kanepe, I.; Shestakova, I.; Yashchenko, E.; Lukevics Chem. Heterocycl. Compd. 2003, 39, 587. [Khim. Geterotsikl. Soedin. 2003, 680.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1025185830067

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Published

2003-05-25

Issue

No. 5 (2003)

Section

Original Papers