ONE-POT REDUCTIVE AMINATION OF 2-AZIDOBENZALDEHYDES WITH ALIPHATIC AMINES, N-PROPARGYLATION AND INTRAMOLECULAR (3+2) CYCLOADDITION FOR THE SYNTHESIS OF N-SUBSTITUTED TRIAZOLOBENZODIAZEPINES

Authors

  • Wensheng Zhang School of Material Engineering, Engineering Technology Research Center for Refinement and Resource Recycling of Metal Materials in Henan Province, Jiyuan Vocational and Technical College, Jiyuan 459000
  • Wei Zheng School of Material Engineering, Engineering Technology Research Center for Refinement and Resource Recycling of Metal Materials in Henan Province, Jiyuan Vocational and Technical College, Jiyuan 459000
  • Xinling Du School of Material Engineering, Engineering Technology Research Center for Refinement and Resource Recycling of Metal Materials in Henan Province, Jiyuan Vocational and Technical College, Jiyuan 459000
  • Gaiyun Liu School of Material Engineering, Engineering Technology Research Center for Refinement and Resource Recycling of Metal Materials in Henan Province, Jiyuan Vocational and Technical College, Jiyuan 459000
  • Lvchen Wu School of Material Engineering, Engineering Technology Research Center for Refinement and Resource Recycling of Metal Materials in Henan Province, Jiyuan Vocational and Technical College, Jiyuan 459000

Keywords:

triazolobenzodiazepine, (3+2) cycloaddition, reductive amination, synthesis

Abstract

An efficient and pot-economic synthetic approach toward N-substituted triazolobenzodiazepines is presented. This efficient one-pot synthesis, involving the reductive amination of 2-azidobenzaldehydes with benzyl/alkyl amines, followed by N-propargylation and intramolecular (3+2) cycloaddition, generates a variety of N-substituted triazolobenzodiazepines in satisfactory yields.

Published

2026-05-15

Issue

Vol. 61 No. 11/12 (2025)

Section

Original Papers