Stereochemistry of the asymmetric alkylation of Δ<sup>9,10</sup>-octahydroquinolin-4-ones
Abstract
The asymmetric character of the alkylation of a series of metallated bicyclic enaminoketones has been established and its stereoselectivity has been investigated. The enantiomers of (3S*)-methyl- and (3S*)- and (3R*)-3-methyl-3′-butyl-Δ9,10-octahydroquinolin-4-ones have been obtained. The possibility of inducing chirality at the 3 position of the enaminoketone molecule during methylation in the presence of chiral lithium amides has been established in principle.
How to Cite
Grishina, G. V.; Gaidarova, E. L. Chem. Heterocycl. Compd. 1995, 31, 1328. [Khim. Geterotsikl. Soedin. 1995, 1531.]
For this article in the English edition, see DOI https://doi.org/10.1007/BF01168628
