AN ENVIRONMENTALLY BENIGN AND SOLVENT-FREE SYNTHESIS OF 3-ARYL[1,2,4]TRIAZOLO[4,3-<i>a</i>]PYRIDINES AND 1-ARYL-5-METHYL[1,2,4]TRIAZOLO[4,3-<i>a</i>]QUINOLINES USING PHENYLIODINE BIS(TRIFLUOROACETATE) OR IODOBENZENE DIACETATE

Abstract

A simple, solvent-free and effective method for oxidative cyclization of 2-pyridyl and 2-quinolylhydrazones with phenyliodine bis(trifluoroacetate) and iodobenzene diacetate to corresponding 3-aryl-[1,2,4]triazolo[4,3-a]pyridines and 1-aryl-[1,2,4]triazolo[4,3-a]quinolines is described. All reactions were characterized by short reaction times and high yields at room temperature. All reactions were carried out just by grinding the reaction components.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (10), pp 1237-1243

http://link.springer.com/article/10.1007/s10593-012-0899-0