SYNTHESIS OF SUBSTITUTED 2-PYRIDONES USING ARYLAMIDOESTERS OF MALONIC ACID

Authors

  • С. С. Айоцян Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • А. Г. Асратян Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • С. Г. Конькова Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • А. Х. Хачатрян Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • А. Э. Бадасян Center for Molecular Structure Research, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • А. Г. Айвазян Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • Г. А. Паносян Center for Molecular Structure Research, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
  • М. С. Саргсян Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

DOI:

https://doi.org/10.1007/1770

Keywords:

amidoester of malonic acid, ethoxymethylideneacetylacetone, 2-pyridone, Michael addition

Abstract

With the aim of developing of the new methods for the synthesis of substituted 2-pyridones, the reaction of arylamidoesters of malonic acid with ethoxymethylideneacetylacetone in the presence of triethylamine in ethanol solution was studied. NMR spectroscopy and X-ray diffraction structural analysis of the reaction product indicated that the forming enedione undergoes the Michael reaction to provide substituted 2‑pyridones.

How to Cite
Hayotsyan, S. S.; Hasratyan, A. H.; Kon'kova, S. G.; Khachatryan, A. Kh.; Badasyan, A. E.; Ayvazyan, A. G.; Panosyan, G. A.; Sargsyan, M. S. Chem. Heterocycl. Compd. 2014, 50, 1126. [Khim. Geterotsikl. Soedin. 2014, 1221.]

For this article in the English edition see DOI 10.1007/s10593-014-1572-6

Author Biographies

С. С. Айоцян, Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Саргис С. Айоцян

А. Г. Асратян, Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Ани Г. Асратян

С. Г. Конькова, Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Светлана Г. Конькова

А. Х. Хачатрян, Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Ануш Х. Хачатрян

А. Э. Бадасян, Center for Molecular Structure Research, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Алик Э. Бадасян

А. Г. Айвазян, Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Армен Г. Айвазян

Г. А. Паносян, Center for Molecular Structure Research, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Генрих А. Паносян

М. С. Саргсян, Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Мушег С. Саргсян

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Published

2014-09-08

Issue

No. 8 (2014)

Section

Original Papers