ALKYLATION OF 3-AMINOISOCARBOSTYRYL DERIVATIVES

Abstract

The alkylation of derivatives of 3-aminoisoquinolin-1(2H)-one in the presence of NaH may proceed in three directions: 1) at the carbonyl group oxygen atom, 2) at the nitrogen atom N-2, and 3) at the 3-amino group. The reaction of equivalent amounts of the reagents gives predominantly products of substitution at the 3-amino group. Repeated alkylation proceeds at the lactam fragment to give a mixture of O-alkyl and N-alkyl derivatives. Acylation of 3-dialkylamino- and 3-alkylanilinoisoquinolin-1(2H)-ones in the presence of NaH gave derivatives of 3-amino-1-isoquinolinyl 4-ethoxybenzoate.

How to Cite
Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.; Turov, A. V. Chem. Heterocycl. Compd. 2011, 47(3), 309. [Khim. Geterotsikl. Soedin. 2011, 379.]

For this article in the English edition see DOI 10.1007/s10593-011-0758-4