2- AND 3 PHENYLSULFONYLINDOLES – SYNTHETIC EQUIVALENTS OF UNSUBSTITUTED INDOLE IN N-ALKYLATION REACTIONS

Authors

  • А. В. Карчава M. V. Lomonosov Moscow State University
  • И. С. Шулева M. V. Lomonosov Moscow State University
  • A. А. Овчаренко M. V. Lomonosov Moscow State University
  • М. А. Юровская M. V. Lomonosov Moscow State University

DOI:

https://doi.org/10.1007/2834

Keywords:

indoles, N-alkylation, reduction desulfonylation, Mitsunobu reaction

Abstract

The N‑alkylation of 2‑ and 3‑phenylsulfonylindoles under various conditions and the subsequent removal of the activating phenylsulfonyl group by reductive desulfonylation using Raney nickel leads to N‑alkylindoles in high yield. 2‑Phenylsulfonylindole readily undergoes the Mitsunobu reaction, while isomeric 3‑phenylsulfonylindole is relatively inert under these conditions.

How to Cite
Karchava, A. V.; Shuleva, I. S.; Ovcharenko, A. A.; Yurovskaya, M. A. Chem. Heterocycl. Compd. 2010, 46, 291. [Khim. Geterotsikl. Soedin. 2010, 373.]

For this article in the English edition see DOI 10.1007/s10593-010-0504-3

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Published

2015-12-03

Issue

No. 3 (2010)

Section

Original Papers