SYNTHESIS OF NEW PYRROLO[2,1-<i>a</i>]PHTHALAZINE DERIVATIVES <i>VIA</i> MULTICOMPONENT REACTION OF PHTHALAZINE WITH 1,1-DICYANOALKENES AND ALKYL ISOCYANIDES

Abstract

Multicomponent reactions between phthalazine, alkyl isocyanides, and 1,1-dicyanoalkenes in acetonitrile–water mixture produced high yields of substituted pyrrolo[2,1-a]phthalazines, which were converted upon treatment with 10% hydrochloric acid to pyrrolo[2,1-a]phthalazines unsubstituted at position 1. As a result, a range of new pyrrolo[2,1-a]phthalazine derivatives have been synthesized by this one-pot approach.