SYNTHESIS OF NEW PYRROLO[2,1-<i>a</i>]PHTHALAZINE DERIVATIVES <i>VIA</i> MULTICOMPONENT REACTION OF PHTHALAZINE WITH 1,1-DICYANOALKENES AND ALKYL ISOCYANIDES

Авторы

  • Maxim A. Mironov Уральского Федерального Университета имени первого Президента России Б.Н. Ельцина
  • Iliya D. Shulepov Ural Federal University
  • Ksenia V. Kozhikhova Ural Federal University
  • Maria N. Ivantsova Ural Federal University
  • Maria I. Tokareva Ural Federal University

DOI:

https://doi.org/10.1007/3688

Ключевые слова:

phthalazine, multicomponent reaction, isocyanides, decarboxylation, one-pot synthesis

Аннотация

Multicomponent reactions between phthalazine, alkyl isocyanides, and 1,1-dicyanoalkenes in acetonitrile–water mixture produced high yields of substituted pyrrolo[2,1-a]phthalazines, which were converted upon treatment with 10% hydrochloric acid to pyrrolo[2,1-a]phthalazines unsubstituted at position 1. As a result, a range of new pyrrolo[2,1-a]phthalazine derivatives have been synthesized by this one-pot approach.

 

Биография автора

Maxim A. Mironov, Уральского Федерального Университета имени первого Президента России Б.Н. Ельцина

Porf. Department of technology for organic synthesis

Загрузки

Опубликован

2017-05-02

Выпуск

Том 53 № 4 (2017): Многокомпонентные реакции в синтезе гетероциклов

Раздел

Оригинальные статьи