[3+2] CYCLOADDITION-BASED ONE-POT SYNTHESIS OF 3,9-DIAZABICYCLO[4.2.1]NONANE-CONTAINING SCAFFOLD

Authors

  • Xiaofeng Zhang Center for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston MA 02125
  • Marc Legris Center for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston MA 02125
  • Alex M. Muthengi Center for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston MA 02125
  • Wei Zhang Center for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston MA 02125

DOI:

https://doi.org/10.1007/3722

Keywords:

3, 9-diazabicyclo[4.2.1]nonane, [3 2] cycloaddition, 1, 3-dipolar cycloaddition, multicomponent reaction, one-pot synthesis

Abstract

Three-component [3+2] cycloaddition followed by reduction and lactamization has been developed as a one-pot methodology for diastereoselective synthesis of 3,9-diazabicyclo[4.2.1]nonane-containing scaffold.

Author Biography

Wei Zhang, Center for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston MA 02125

Professor and Director of the Center for Green Chemistry

Downloads

Published

2017-05-09

Issue

Vol. 53 No. 4 (2017): Multicomponent reactions in the synthesis of heterocycles

Section

Original Papers