ADDITION REACTION OF VARIOUS AZOLES TO PERFLUOROMETHYL VINYL ETHER

Authors

  • Kirill I. Petko Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02660, Ukraine
  • Andrey A. Filatov Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02660, Ukraine Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine

DOI:

https://doi.org/10.1007/6253

Keywords:

azoles, perfluoromethylvinyl ether, addition reaction, lipophilicity.

Abstract

The addition reaction of perfluoromethyl vinyl ether to various azoles – derivatives of pyrrole, imidazole, pyrazole, indole, benzotriazole, carbazole, and triazole has been demonstrated. The reaction conditions depended both on melting point and nucleophilicity of the heterocycle. The obtained products are hydrolytically and thermally stable, have highly lipophilic moiety and can serve as useful precursors in different synthesis of bioactive compounds.

Author Biographies

Kirill I. Petko, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02660, Ukraine

Отдел химии фтора Старший научный сотрудник

Andrey A. Filatov, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02660, Ukraine Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine

Отдел химии фтора. Младший научный сотрудник. Координатор поставок реактивов фирмы Енамин

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Published

2021-06-19

Issue

Vol. 57 No. 6 (2021)

Section

Original Papers