SYNTHESIS OF 3-SUBSTITUTED TETRAHYDROINDOL-4-ONE
DOI:
https://doi.org/10.1007/6418Keywords:
acetylacetone, arylglyoxal hydrates, 3-[(5, 5-dimethyl-3-oxocyclohex-1-en-1-yl)amino]propanoic acid, (5, 5-dimethyl-3-oxocyclohex-1-en-1-yl)glycine, 4-hydroxycoumarin, tetrahydroindol-4-ones, cyclocondensation, synthesis.Abstract
A series of functionalized 4,5,6,7-tetrahydroindol-4-one derivatives containing a residue derived from β-dicarbonyl compound at position 3 were prepared by a reaction of cyclic enaminones, arylglyoxal hydrates, and β-dicarbonyl compounds. Modification of acetyl-acetone residue at position 3 of tetrahydroindoles was accomplished by condensation with 1,2- and 1,4-bisnucleophiles.
