4-HYDROXY-2-QUINOLONES. 166. SYNTHESIS, ISOMERISM, AND ANTITUBERCULAR ACTIVITY OF 3-ARYLAMINOMETHYLENEQUINOLINE-2,4-(1H,3H)-DIONES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Лю Янян National University of Pharmacy, Kharkiv 61002
  • А. А. Ткач National University of Pharmacy, Kharkiv 61002
  • А. В. Туров Taras Shevchenko National University, Kiev 01033

DOI:

https://doi.org/10.1007/6639

Keywords:

anilines, 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carbaldehydes, enamines, Schiff bases, isomerism, antitubercular activity, tautomerism

Abstract

Condensation of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbaldehydes, thioglycolic acid (or methyl thioglycolate), and anilines does not lead to the synthesis of the corresponding thiazolidinylquinolones because the Schiff bases so formed exist exclusively in a form inert to enamine thioglycolates. 1H NMR spectroscopy showed that the main components  of the isolated 3-arylaminomethylenequinoline-2,4-(1H,3H)-diones are E-isomers. The results of  a study of the antitubercular properties of the compounds obtained are presented.

How to Cite
Ukrainets, I. V.; Yangyang, L.; Tkach, A. A.; Turov, A. V.  Chem. Heterocycl. Compd. 2009, 45, 802. [Khim. Geterotsikl. Soedin. 2009, 1015.]

For this article in the English edition see DOI 10.1007/s10593-009-0356-x


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Published

2022-03-01

Issue

No. 7 (2009)

Section

Original Papers