A SIMPLE ROUTE FOR THE SYNTHESIS OF SUBSTITUTED THIAZOLE DERIVATIVES BY MULTICOMPONENT REACTION BETWEEN ARYLGLYOXALS, ACETYLACETONE OR ETHYL ACETOACETATE, AND THIOSEMICARBAZONES

Authors

  • Mahsa Latifi Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, 22 Bahman Sq., Rafsanjan 77176, Iran
  • Mohammad Anary-Abbasinejad Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, 22 Bahman Sq., Rafsanjan 77176, Iran
  • Marziyeh Mohammadi Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, 22 Bahman Sq., Rafsanjan 77176, Iran

DOI:

https://doi.org/10.1007/7255

Keywords:

acetylacetone, arylglyoxals, ethyl acetoacetate, thiazole, multicomponent reaction.

Abstract

An effective one-pot three-component protocol for the synthesis of polysubstituted thiazole derivatives is reported. The reaction proceeds between arylglyoxals, thiosemicarbazones, and acetylacetone or ethyl acetoacetate in ethanol as solvent and in the presence of acetic acid as catalyst.

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Published

2023-11-01

Issue

Vol. 59 No. 9/10 (2023)

Section

Original Papers