NOVEL CATIONIC CONJUGATES OF CHLORIN <i>e</i><sub>6</sub> WITH GALACTOSE FRAGMENTS: SYNTHESIS AND EVALUATION OF PHOTODYNAMIC ACTIVITY

Authors

  • Marina V. Malshakova Institute of Chemistry, Komi Scientific Centre, Ural Branch of the RAS, 48 Pervomayskaya St., Syktyvkar 167000
  • Yana I. Pylina Institute of Biology, Komi Scientific Centre, Ural Branch of the RAS, 28 Kommunisticheskaya St., Syktyvkar 167000
  • Dmitry V. Belykh Institute of Chemistry, Komi Scientific Centre, Ural Branch of the RAS, 48 Pervomayskaya St., Syktyvkar 167000

DOI:

https://doi.org/10.1007/7883

Keywords:

aminochlorins, chlorin е6, 1, 2, 3, 4-di-O-isopropylidene-1-O-(trifluoromethanesulfonyl)-α-D-galactopyranose, galactose, methyl pheophorbide а, alkylation, cytotoxicity, quaternization

Abstract

Water-soluble chlorin e6 cationic derivatives with one and two galactose fragments at the quaternized nitrogen atom were synthesized, and the dark and photoinduced cytotoxicity of the obtained compounds was evaluated.

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Published

2023-11-01

Issue

Vol. 59 No. 9/10 (2023)

Section

Original Papers