NOVEL CATIONIC CONJUGATES OF CHLORIN <i>e</i><sub>6</sub> WITH GALACTOSE FRAGMENTS: SYNTHESIS AND EVALUATION OF PHOTODYNAMIC ACTIVITY

Авторы

  • Marina V. Malshakova Institute of Chemistry, Komi Scientific Centre, Ural Branch of the RAS, 48 Pervomayskaya St., Syktyvkar 167000
  • Yana I. Pylina Institute of Biology, Komi Scientific Centre, Ural Branch of the RAS, 28 Kommunisticheskaya St., Syktyvkar 167000
  • Dmitry V. Belykh Institute of Chemistry, Komi Scientific Centre, Ural Branch of the RAS, 48 Pervomayskaya St., Syktyvkar 167000

DOI:

https://doi.org/10.1007/7883

Ключевые слова:

aminochlorins, chlorin е6, 1, 2, 3, 4-di-O-isopropylidene-1-O-(trifluoromethanesulfonyl)-α-D-galactopyranose, galactose, methyl pheophorbide а, alkylation, cytotoxicity, quaternization

Аннотация

Water-soluble chlorin e6 cationic derivatives with one and two galactose fragments at the quaternized nitrogen atom were synthesized, and the dark and photoinduced cytotoxicity of the obtained compounds was evaluated.

Загрузки

Опубликован

2023-11-01

Выпуск

Том 59 № 9/10 (2023)

Раздел

Оригинальные статьи