QUANTUM-CHEMICAL INVESTIGATION OF THE MECHANISM OF CYCLOCONDENSATION OF 4-HYDROXY-4-METHYLPENTAN-2-ONE WITH CYANOACETAMIDE USING THE AM1 METHOD

Abstract

The mechanism of formation of 4,6,6-trimethyl-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile from 4-hydroxy-4-methylpentan-2-one and cyanoacetamide in  the presence of ammonium acetate has been studied by the AM1 method. It  was  found that,  under the reaction conditions, the amide is readily converted to an iminol tautomeric form which takes part in subsequent reaction. It was shown that the reaction is a cascade process forming two intermediates. The final product 4,6,6-trimethyl-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile is formed from the product of a Knoevenagel condensation via an intramolecular nucleophilic substitution mechanism. On the basis of the activation energies obtained it can be deduced that the limiting stage is the deprotonation process of the cyanoacetiminol.

How to Cite
Fleisher, M.; Jansone, D.; Leite, L.; Lukevics, E.  Chem. Heterocycl. Compd. 2006, 42, 184. [Khim. Geterotsikl. Soedin. 2006, 209.]

For this article in the English edition, see DOI 10.1007/s10593-006-0069-3