SOME CHEMICAL TRANSFORMATIONS OF 4,5-DIHYDRO-5-METHYL-3H-SPIRO[BENZ-2-AZEPINE-3,1'-CYCLOHEXANE] N-OXIDE

Authors

  • А. В. Варламов Russian People's Friendship University, Moscow 117198
  • Д. Г. Грудинин Russian People's Friendship University, Moscow 117198
  • А. И. Чернышев Russian People's Friendship University, Moscow 117198

Keywords:

benz-2-azepines, isoxazolidino- and oxadiazolidino[3,2-a]benz-2-azepines, cyclic nitrones, reduction, nucleophilic addition, oxidation

Abstract

The oxidation and reduction of 4,5-dihydro-5-methyl-3H-spiro[benz-2-azepine-3,1'-cyclohexane] N-oxide, the reactions of this N-oxide with methylmagnesium iodide, the sodium salt of diethyl malonate, phenyl isocyanate, and its rearrangement by the action of acetic anhydride lead to N-hydroxy-1,2,3,4-tetrahydrobenz-2-azepines, benz-2-azepine-1-one, and its N-acetoxy derivative as well as isoxazolidino- and oxadiazolidino[3,2-a]benz-2-azepines spirofused with a cyclohexane ring.

How to Cite
Varlamov, A. V.;  Grudinin, D. G.; Chernyshev, A. I. Chem. Heterocycl. Compd. 2004, 40, 622. [Khim. Geterotsikl. Soedin. 2004, 736.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000037318.38320.7b

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Published

2004-05-25

Issue

No. 5 (2004)

Section

Original Papers