REACTION OF ESTERS OF 2-SUBSTITUTED 5-PYRIMIDINECARBOXYLIC ACIDS WITH HYDRAZINE HYDRATE

Abstract

The reaction of methyl esters of 2-substituted 5-pyrimidinecarboxylic acids with hydrazine hydrate at 0-5°C results in the nucleophilic substitution of readily eliminating groups (Cl, CH₃O, CH₃S) at the position 2 of the pyrimidine ring, and, on the boiling with the 80% aqueous solution of hydrazine hydrate , the reaction is accompanied by the formation of hydrazides. The dimethylamino group at the position 2 of the pyrimidine ring is not substituted by hydrazine.

Authors: S. Tumkevicius, V. Yakubkene, and P. Vainilavicius.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (11), pp 1334-1336

http://link.springer.com/article/10.1007/BF02252004