Reaction of 3-cyanopyridine-2(1H)-thiones with <i>n</i>-butyllithium

Authors

  • Н. Г. Фролова N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • B. К. Завьялова N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow
  • В. П. Литвинов N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow

Abstract

The reaction of 3-cyanopyridine-2(1H)-thiones with BuLi in ether was studied. It was found that the metallation proceeds initially at the sulfur atom. The resulting lithium salts add a second equivalent of n-butyllithium at the CN group. The hydrolysis of the dilithium derivatives leads to 3- pentanoylpyridine-2(1H)-thiones.

How to Cite
Frolova, N. G.; Zav'yalova, V. K.; Litvinov, V. P. Chem. Heterocycl. Compd. 1996, 32, 26. [Khim. Geterotsikl. Soedin. 1996, 231.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01165448

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Published

1996-02-25

Issue

No. 2 (1996)

Section

Original Papers