Porphyrins. 33. Proton magnetic resonance spectra of hematoporphyrin derivatives. Properties of a dimethoxy derivative (dimegin) in aqueous solution

Authors

  • Т. А. Бабyшкина Institute of Biophysics, Russian State Scientific Center, 123182, Moscow
  • Г. В. Кириллова Institute of Biophysics, Russian State Scientific Center, 123182, Moscow
  • Г. B. Пономарев Institute of Biological and Medicinal Chemistry, Russian Academy of Medical Sciences, 119832, Moscow

Abstract

The PMR spectra of derivatives of hematoporphyrin IX have been investigated in organic and aqueous solution. It has been shown that the presence of the two chiral centers at positions 2 and 4 of the macrocycle is displayed in the specific splitting of the signals of the meso protons. The structures of dimeric associates of 2,4-di(α-methoxyethyl)-deuteroporphyrin IX (dimegin) have been studied in aqueous solution over a wide pH range and have the structure of a “skewed sandwich” according to PMR data.

How to Cite
Babushkina, T. A.; Kirillova, G. V.; Ponomarev, G. V. Chem. Heterocycl. Compd. 1996, 32, 174. [Khim. Geterotsikl. Soedin. 1996, 198.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01165441

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Published

1996-02-25

Issue

No. 2 (1996)

Section

Original Papers