SYNTHESIS AND REACTIONS OF 1,2-BIS[3-CYANO-4-(2-FLUOROPHENYL)-6-OXO-1,4,5,6-TETRAHYDROPYRIDIN-2-YL]DISELANE

Abstract

The interaction of 2-fluorobenzaldehyde, cyanoselenoacetamide and Meldrum's acid in the presence of N-methylmorpholine gives 1,2-bis[3-cyano-4-(2-fluorophenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]di-selane, which also is the product of the reaction of cyanoselenoacetamide with 5-(2-fluorobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione. The diselane obtained interacts with alkyl halides in the presence of a base, forming the corresponding 4-(2-fluorophenyl)-2-(2-R-methylselanyl)-6-oxo-1,4,5,6-tetra-hydropyridine-3-carbonitriles.

Authors: K. A. Frolov, V. V. Dotsenko, and S. G. Krivokolysko.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (7), pp 1006-1010

http://link.springer.com/article/10.1007/s10593-012-1092-1