SYNTHESIS, STRUCTURAL ASPECTS, AND ANTIMICROBIAL ACTIVITY INVESTIGATION OF NOVEL MACROCYCLIC AMIDE CONTAINING COMPOUNDS

Abstract

Macrocyclic 1⁶,7⁶-dimethyl-1,7(2,4)-ditriazina-2,6,8,12-tetraaza-3,5,9,11-tetraoxocyclododecaphane, 1⁶,8⁶-dimethyl-1,8(2,4)-ditriazina-2,7,9,14-tetraaza-3,6,10,13-tetraoxocyclotetradecaphane, 1⁶,9⁶-dimethyl-1,9(2,4)-ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxocyclohexadecaphane, and 1⁶,10⁶-dimethyl-1,10(2,4)-ditriazina-2,9,11,18-tetraaza-3,8,12,17-tetraoxocyclooctadecaphane are synthesized. The compounds are characterized by elemental analyses, Raman, IR, ¹H, ¹³C NMR and mass spectral data. The antimicrobial activities of the compounds are evaluated against several bacteria and yeast cultures and the results were compared with those of commercial antibiotic and antifungal agents. Structure–activity relationships are also discussed.

Also published in Chemistry of Heterocyclic Compounds, 2012, 48 (6), pp 936-942

http://link.springer.com/article/10.1007/s10593-012-1080-5