STEREOCHEMISTRY OF THE AZA-MICHAEL REACTION WITH NATURAL ALANTOLACTONES
DOI:
https://doi.org/10.1007/1185Keywords:
alantolactones, 3-aminomethyldecahydronaphtho[2, 3-b]furan-2-ones, aza-Michael reaction, stereochemistry, two-dimensional NMR, X-ray structural analysisAbstract
Hydrogenated 3-aminomethylnaphtho[2,3-b]furan-2-ones were synthesized by the reaction of natural alantolactones with pharmacophoric amines. Determination of the newly formed asymmetric center configuration by two-dimensional NMR data is presented. The structure of the obtained compounds was proved by X-ray structural analysis.
Authors: S. G. Klochkov, I. V. Anan'ev, S. A. Pukhov, and S. V. Afanas'eva.
English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (5), pp 698-703