MANNICH REACTION IN THE SYNTHESIS OF N,S-CONTAINING HETEROCYCLES. 13. ONE-POT METHOD FOR PREPARING PYRIMIDO[4,3-<i>b</i>][1,3,5]THIADIAZINES BY REACTION OF ALDEHYDES, CYANOTHIOACETAMIDE, FORMALDEHYDE, AND PRIMARY AMINES

Authors

  • В. В. Доценко "ChemEx Laboratory", Vladimir Dal' East-Ukrainian National University
  • К. А. Фролов "ChemEx Laboratory", Vladimir Dal' East-Ukrainian National University
  • С. Г. Кривоколыско "ChemEx Laboratory", Vladimir Dal' East-Ukrainian National University

DOI:

https://doi.org/10.1007/1219

Keywords:

cyanothioacetamide, pyrimido[4, 3-b][1, 3, 5]thiadiazines, aminomethylation, Mannich reaction, multicomponent condensation

Abstract

Successive reaction of cyanothioacetamide with aliphatic or aromatic aldehydes, formaldehyde, and primary amines gives the corresponding 3,7-disubstituted 3,4,7,8-tetrahydro-2H,6H-pyrimido-[4,3-b][1,3,5]thiadiazine-9-carbonitriles.

Authors: V. V. Dotsenko, K. A. Frolov, and S. G. Krivokolysko.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (4), pp 642-649

http://link.springer.com/article/10.1007/s10593-012-1038-7

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Published

2013-11-21

Issue

No. 4 (2012)

Section

Original Papers