FLUORINATED [1,2,4]TRIAZOLO[1,5-<i>a</i>]PYRIMIDINES AND [1,2,4]TRIAZOLO[5,1-<i>c</i>][1,2,4]TRIAZINES

Authors

  • Е. Н. Уломский Ural Federal University
  • Н. Р. Медведева Ural Federal University
  • А. В. Щепочкин Ural Federal University
  • О. С. Ельцов Ural Federal University
  • В. Л. Русинов Ural Federal University; I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
  • О. Н. Чупахин Ural Federal University; I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
  • Э. Г. Деева Research Institute of Influenza, Russian Academy of Medical Sciences
  • О. И. Киселев Research Institute of Influenza, Russian Academy of Medical Sciences

DOI:

https://doi.org/10.1007/1400

Keywords:

fluorinated azines, [1, 2, 4]triazolo[1, 5-a]pyrimidin-7(4H)-ones, 4]triazolo[5, 1-c][1, 4]-triazin-4(1H)-ones

Abstract

The reaction of 3-R-5-amino-1,2,4-triazoles with the ethyl ester of 2-fluoroacetoacetic acid gave 2 R fluoro[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ones. The reaction of a 3-R-1,2,4-triazolyl-5-diazo-nium salt with the ethyl ester of 2-fluoroacetoacetic acid and subsequent cyclization of the triazolylhydrazones lead to 7-R-3-fluoro[1,2,4]triazolo[5,1-c][1,2,4]triazin-4(1H)-ones.

Authors: E. N. Ulomskiy, N. R. Medvedeva, A. V. Shchepochkin, O. S. Eltsov, V. L. Rusinov, O. N. Chupakhin, E. G. Deeva, and O. I. Kiselev.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (9), pp 1164-1169

http://link.springer.com/article/10.1007/s10593-011-0887-9

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Published

2013-12-17

Issue

No. 9 (2011)

Section

Original Papers