SYNTHESIS OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES AND THEIR NUCLEOSIDE ANALOGS WITH ANTIOXIDANT AND ANTITUMOR ACTIVITIES

Authors

  • A. A. Fadda Department of Chemistry, Faculty of Science, Mansoura University
  • A. A.-H. Abdel-Rahman Department of Chemistry, Faculty of Science, Menoufia University
  • W. A. El-Sayed Department of Photochemistry, National Research Center
  • T. A. Zidan Department of Chemistry, Faculty of Science, Mansoura University
  • F. A. Badria Department of Drugs, Faculty of Pharmacology, Mansoura University

DOI:

https://doi.org/10.1007/1487

Keywords:

acyclic nucleosides, 1, 3, 4-oxadiazoles, sugar hydrazones, antioxidant activity, citotoxicity

Abstract

A series of new (1,3,4-oxadiazol-2-yl)-1H-benzo[h]quinolin-4-one derivatives were synthesized, including glucose and xylose hydrazones that were obtained by the reaction of hydrazides with monosaccharides. Cyclization of the sugar hydrazones with
acetic anhydride afforded substituted oxadiazoline derivatives. The newly synthesized compounds were evaluated for their antioxidant properties and cytotoxicity, and showed moderate to high activities.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (7), pp 856-864

http://link.springer.com/article/10.1007/s10593-011-0847-4

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Published

2014-01-17

Issue

No. 7 (2011)

Section

Original Papers