SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF SOME DIBENZOPYRAZOLOCINNOLINES AND DIBENZOPYRIDAZINOQUINOXALINES

Authors

  • A. M. Amer Chemistry Department, Faculty of Science, Zagazig University
  • A. F. El-Farargy Chemistry Department, Faculty of Science, Zagazig University
  • N. M. Yousif National Research Center, Photochemistry Department
  • A. A. Fayed National Research Center, Photochemistry Department

DOI:

https://doi.org/10.1007/2183

Keywords:

pyridazine, pyrimidine, triazine, antiparkinsonian activity

Abstract

Derivatives of three new classes of heterocyclic compounds have been synthesized. The first class comprises the synthesis of pyrimidino- and imidazolopyrazolopyridazine using 11H-dibenzo[f,h]pyrazolo[3,4-c]cinnolin-13-amine. The second class involves the synthesis of triazine derivatives using 11H-dibenzo[f,h]pyrazolo[3,4-c]cinnoline-13-diazonium chloride. The third class deals with the synthesis of polycyclic compounds using dibenzo[f,h]pyridazino[4,5-b]quinoxaline-10,13-diamine. The pharmacological screening has shown that several of these compounds have good antiparkinsonian activities comparable to Benzatropine. The detailed synthesis, spectroscopic data, and pharmacological properties are reported.

How to Cite
Amer, A. M.; El-Farargy, A. F.; Yousif, N. M.; Fayed, A. A. Chem. Heterocycl. Compd. 2011, 47(1), 101. [Khim. Geterotsikl. Soedin. 2011, 129.]

For this article in the English edition see DOI 10.1007/s10593-011-0726-z

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Published

2014-12-18

Issue

No. 1 (2011)

Section

Original Papers