MICROWAVE-ASSISTED SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL PYRAZOLINES

Authors

  • Ashok Dongamanti Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007
  • Mohan Gandhi Devulapally Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007
  • Vikas Kumar Aamate Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007
  • Srinivas Gundu Department of Chemistry, Osmania University, Tamaka, Hyderabad 500 007

DOI:

https://doi.org/10.1007/2356

Keywords:

antimicrobial activity, chalcones, Michael addition, microwave irradiation, pyrazolines

Abstract

A series of 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-7-ol and 6-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-2,2-dimethylchroman-5-ol derivatives have been synthesized from the corresponding chalcones and hydrazine hydrate in the presence of sodium acetate under microwave irradiation involving the Michael addition followed by cycloaddition. All the newly synthesized 18 compounds were screened for their in vitro antimicrobial activity. Most of the compounds displayed very good to excellent antimicrobial activity in comparison to standard drugs streptomycin and nystatin.

How to Cite
Dongamanti, A.; Devulapally, M. G.; Aamate, V. K.; Gundu, S. Chem. Heterocycl. Compd. 2015, 51, 872. [Khim. Geterotsikl. Soedin. 2015, 51, 872.]

For this article in the English edition see DOI 10.1007/s10593-015-1790-6

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Published

2015-10-29

Issue

Vol. 51 No. 10 (2015)

Section

Original Papers