4-HYDROXY-2-QUINOLONES. 177. STUDY OF A STRUCTURE-DIURETIC ACTIVITY RELATIONSHIP IN A SERIES OF 4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE- 3-CARBOXYLIC ACID N-R-AMIDES

Authors

  • И. В. Украинец National University of Pharmacy
  • Н. Л. Березнякова National University of Pharmacy
  • Л. А. Гриневич National University of Pharmacy
  • В. Е. Кузьмин A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences
  • А. Г. Артеменко A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences

DOI:

https://doi.org/10.1007/3052

Keywords:

1-R-4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxamides, tree-type classification, diuretic activity, molecular simplexes, QSAR

Abstract

With the aim of deducing a structure-biological dependence we have carried out the synthesis of quinoline-3-carboxylic acid N-R-amides with a p-methoxyphenyl substituent in the amide part of the molecule. The effects of the compounds prepared on the excretory function of the kidney are discussed. Using a system of simplex descriptors and the method of tree type classification a QSAR model has been constructed which is suitable for prediction of the diuretic activity of novel quinolinecarboxylic acid N-R-amides.

How to Cite
Ukrainets, I. V.; Bereznyakova, N. L.; Grinevich, L. A.; Kuz'min, V. E.; Artemenko, A. G. Chem. Heterocycl. Compd. 2010, 46, 699. [Khim. Geterotsikl. Soedin. 2010, 868.]

For this article in the English edition see DOI 10.1007/s10593-010-0572-4

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Published

2016-02-18

Issue

No. 6 (2010)

Section

Original Papers