SYNTHESIS OF 4-ARYL-2-PYRANYL-7,8-DIHYDROQUINOLIN-5(6<i>H</i>)-ONES CATALYZED BY CERIUM AMMONIUM NITRATE <i>VIA</i> HANTZSCH MULTICOMPONENT REACTION AND THEIR ANTIBACTERIAL ACTIVITY

Authors

  • Gudala Satish Department of Chemistry, National Institute of Technology, Raipur, G.E Road Raipur-492010, C.G.
  • Archi Sharma Department of Chemistry, National Institute of Technology, Raipur, G.E Road Raipur-492010, C.G.
  • Kranthi K. Gadidasu Department of Biotechnology, Kakatiya University, Warangal-506009, Telangana
  • Rajeswar R. Vedula Department of Chemistry, National Institute of Technology, Warangal-506 004, Telangana
  • Santhosh Penta Department of Chemistry, National Institute of Technology, Raipur, G.E Road Raipur-492010, C.G.

DOI:

https://doi.org/10.1007/3095

Keywords:

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one, cerium ammonium nitrate, dehydroacetic acid, 7, 8-dihydroquinolines, antibacterial activity, green synthesis, multicomponent reaction

Abstract

4-Aryl-2-pyranyl-7,8-dihydroquinolin-5(6H)-one derivatives were obtained in excellent yields from 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one, aromatic aldehydes, 5,5-dimethylcyclohexane-1,3-dione, and ammonium acetate by a one-pot multicomponent Hantzsch synthesis in the presence of cerium ammonium nitrate in water. In vitro antibacterial activity of all the newly synthesized compounds was evaluated. Some of the tested compounds showed a promising antibacterial activity against both Gram-positive and Gram-negative bacterial strains.

Author Biography

Gudala Satish, Department of Chemistry, National Institute of Technology, Raipur, G.E Road Raipur-492010, C.G.

Chemistry

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Published

2016-07-19

Issue

Vol. 52 No. 6 (2016)

Section

Original Papers