SYNTHETIC APPROACHES TO 4-(HET)ARYL-3,4-DIHYDROQUINOLIN-2(1<i>H</i>)-ONES

Authors

  • Inese Mieriņa Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3/7 Paula Valdena St, Riga LV 1048
  • Māra Jure Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3/7 Paula Valdena St, Riga LV 1048
  • Agnese Stikute Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3/7 Paula Valdena St, Riga LV 1048

DOI:

https://doi.org/10.1007/3320

Keywords:

4-(het)aryl-3, 4-dihydroquinolin-2(1H)-ones, lactams, nitrogen heterocycles, multicomponent reactions, Friedel–Crafts reactions

Abstract

This review summarizes strategies for the synthesis of 4-(het)aryl-3,4-dihydroquinolin-2(1H)-ones which are of interest due to their biological activity. It covers methods elaborated particularly for obtaining the title heterocycles, as well as procedures where these compounds are formed as side products. 4-Aryl-3,4-dihydroquinolin-2(1H)-one derivatives have been used for the synthesis of valuable molecules, e.g,. anticancer drug tipifarnib.

Author Biography

Inese Mieriņa, Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3/7 Paula Valdena St, Riga LV 1048

Faculty of Material Science and Applied Chemistry

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Published

2016-09-15

Issue

Vol. 52 No. 8 (2016)

Section

Review Articles