PRIVILEGED HETEROCYCLES: BIOACTIVITY AND SYNTHESIS OF 1,9-DIAZASPIRO[5.5]UNDECANE-CONTAINING COMPOUNDS

Authors

  • Daniel Blanco-Ania Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen
  • Rik Heus Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen
  • Floris P. J. T. Rutjes Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen

DOI:

https://doi.org/10.1007/3874

Keywords:

1, 9-diazaspiro[5.5]undecane, 9-diazaspiro[5.5]undecan-2-one, spiro dipiperidines, obesity, pain treatment

Abstract

This review discusses the biological activity and synthesis of 1,9-diazaspiro[5.5]undecanes, including those ring-fused with arenes and heteroarenes and/or containing a carbonyl group at position 2. These compounds could be used for the treatment of obesity, pain, as well as various immune system, cell signaling, cardiovascular, and psychotic disorders.

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Published

2017-10-03

Issue

Vol. 53 No. 8 (2017)

Section

Review Articles