4-HYDROXYCOUMARINS AS MICHAEL DONORS IN ASYMMETRIC ROUTES TO POLYCYCLIC COUMARINS (MICROREVIEW)

Authors

  • Mariagrazia Rullo Department of Pharmacy - Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy
  • Leonardo PISANI Department of Pharmacy - Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy

DOI:

https://doi.org/10.1007/4499

Keywords:

4-hydroxycoumarins, fused coumarins, asymmetric synthesis, Michael addition.

Abstract

Different [3,4]-fused polycyclic 2H-chromen-2-ones can be prepared in a stereoselective fashion starting from 4-hydroxycoumarins as nucleophilic synthones. Herein we report a brief overview of the most recent methods including Pd-catalyzed [3+3] annulation processes, organocatalytic one-pot and domino Michael addition/cyclization, tandem conjugate addition/hydroxyalkylation, and organocascade catalytic reaction.

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Published

2018-06-04

Issue

Vol. 54 No. 4 (2018): Stereoselective synthesis of heterocyclic compounds

Section

Heterocycles in Focus